Magnesium is an essential nutrient for bone formation and maintenance.* PhysioLogics’ Magnesium Chelate provides Magnesium Glycinate, an absorbable form, for those who want to ensure they obtain a daily supply of this vital component of over 300 essential metabolic reactions to help maintain cellular energy levels and support nerve and bone health through all stages of life.*
STRUCTURE AND FUNCTION
Magnesium is an essential ubiquitous cation that plays a fundamental role in more than 300 enzymatic reactions. Necessary for the anatomical and functional integrity of various subcellular organelles, it participates in every major metabolic pathway, including nucleic acid, protein, carbohydrate, and lipid metabolism. As a cofactor of adenosine triphosphatases, Magnesium ions play a fundamental role in the synthesis, transfer, storage and utilization of energy-rich compounds.*
Magnesium supports healthy nerve cell function. Its presence in adequate amounts in the synaptic gap between neurons modulates the rate at which nerves fire. If Magnesium levels are insufficient, neurons fire too easily, resulting in excessive sensitivity to various stimuli. Magnesium is a component of the muscle enzyme creatine kinase and is needed at the neuromuscular junction in order for muscles to relax.*
Magnesium plays a key role in bone health. The human skeleton utilizes 55% of the body's magnesium. Magnesium directly influences both matrix and mineral metabolism in bone, and aids in the absorption of Calcium by promoting the secretion of calcitonin, a hormone that aids in the influx of calcium into bone. In addition, Magnesium plays a role in modulating the secretion of parathyroid hormone, whose function is to draw Calcium out of bones and deposit it in soft tissue.*
The importance of Magnesium in healthy cardiovascular function has long been recognized. Epidemiological studies found that communities with sufficient levels of Magnesium in drinking water tended to have more support of heart health. Extracellular Magnesium ions exert important effects upon transport and release of Calcium ions in the vascular system, supporting healthy vascular tone.*
The National Health and Nutrition Examination Survey (NHANES III-1988-91) and the Continuing Survey of Food Intakes of Individuals (1994 CSFII) suggest that the diets of most adult Americans do not provide the recommended amounts of Magnesium. In addition, certain regularly prescribed drugs may cause Magnesium depletion. PhysioLogics' Magnesium Chelate may be a desirable dietary supplement for clients who want to support cellular energy synthesis as well as nerve, bone and cardiovascular health.*
HOW CLIENTS MAY BENEFIT
For adults, take two (2) caplets daily, preferably with a meal or follow the advice of your health care professional. As a reminder, discuss the supplements and medications you take with your health care providers.
Abarbanel HD, Gibb L, Huerta R, Rabinovich MI. Biol Cybern. 2003 Sep;89(3):214-26. Epub 2003 Jul 31.
Alaimo K, McDowell, M.A., Briefel, R.R, Bischlf, A.M, Caughman, C.R, Loria, C.M, Johnson, C.L. 1988- 91. In: Johnson GV, ed. National Center for Health Statistics, Hyattsville, MD 1994:1-28.
Altura BM, Zhang A, Altura BT. Miner Electrolyte Metab. 1993;19(4-5):323-36. Review.
Brautbar N, Carpenter C. 1984;3(2):57-62.
Dimai HP, Porta S, Wirnsberger G, Lindschinger M, Pamperl I, Dobnig H, Wilders-Truschnig M, Lau KH. J Clin Endocrinol Metab. 1998 Aug;83(8):2742-8.
Dreosti IE. Nutr Rev. 1995 Sep;53(9 Pt 2):S23-7.
Ferment O, Touitou Y. Comp Biochem Physiol A. 1985;82(4):753-8.
National Academy Press. Washington, DC, 1999.
Matkovic V. J Am Coll Nutr. 1996. 15(6):556-69
Rasmussen HS, Aurup P, Goldstein K, McNair P, Mortensen PB, Larsen OG, Lawaetz H. Arch Intern Med. 1989 May;149(5):1050-3.
Rude RK and Olerich M. 1996;6:453-61.
Sojka JE, Weaver CM. Nutr Rev. 1995 Mar;53(3):71-4.
Tanabe K, Yamamoto A, Suzuki N, Osada N, Yokoyama Y, Samejima H, Seki A, Oya M, Murabayashi T, Nakayama M, Yamamoto M, Omiya K, Itoh H, Murayama M. Jpn Circ J. 1998 May;62(5):341-6.