PRODUCT IS ALSO KNOWN AS:
Clinical trials involving orally supplemented melatonin have implicated this indoleamine to have positive metabolic interactions on various sleep parameters.* PhysioLogic's supplies Melatonin at dosage levels consistent with published research which demonstrates its ability to promote calm, restful sleep.* Melatonin may also prove to be useful for frequent travelers experiencing jet lag.*
STRUCTURE AND FUNCTION
The pineal gland is the organ where information about light and dark is processed and then relayed to cells throughout the body. The eyes deliver information to the pineal gland through different routes that include the retinohypothalamic tract and the suprachiasmatic nuclei. Norepinephrine released from postganglionic nerve endings to the pineal gland helps control melatonin release. This release of norepinephrine to the pinealocytes occurs at night, which is when melatonin secretion and levels throughout the body begin to rise.*
Melatonin, due to its considerable lipophilicity, is able to cross any cell membrane and enter any tissue or cellular compartment.* Therefore it is likely that some of melatonin's biochemical effects are elicited through intracellular binding sites in addition to its interactions with membrane-bound receptors (Hardeland, 95). Melatonin's high lipophilicity is what allows it to transmit the signal of darkness to every cell in the body, in turn acting as the eyes for each cell, organ and tissue.* This is why melatonin levels throughout the body are so important for promoting calm, restful sleep and a relaxed mood in the evening by supporting natural circadian rhythms.*
In addition to its effects on sleep, Melatonin is believed to play a major role in the biological termination of free-radical induced redox reactions.* Melatonin is reported to have a large capacity to trap hydroxyl radicals, the free radical species with the highest relative reactivity.* Melatonin also efficiently traps peroxyl radicals and superoxide anions.* Melatonin participates in a two-step process in which it first interacts with a hydroxyl or peroxyl radial to give a melatonyl cation radical, which then combines with a superoxide anion to neutralize the electrical charges and pairing electrons.*
Occasional sleeplessness can affect anyone - young or old. The National Institutes of Health recommends to keep a regular schedule of going to bed and waking up at the same time every day, even on weekends, to help your body maintain a normal circadian rhythm. However, due to life's demands this is not realistic for many people. Endogenous melatonin is an important component of your body's circadian rhythm. Supplemental melatonin can provide circadian rhythm support for calm, restful sleep - especially when experiencing occasional sleeplessness or jet lag.*
HOW CLIENTS MAY BENEFIT
When it comes to supporting nocturnal sleep patterns, melatonin is the #1 supplement in terms of clinical trials and efficacy. Melatonin's ability to interact with membrane-bound receptors as well as intracellular binding sites help translate the message of darkness and sleep to each cell in the body. Just one tablet can be taken in the evening to help promote a relaxed mood and restful sleep. Physiologics offers high-quality melatonin that is vegetarian-suitable, free of substantial allergenic materials and dosed at levels consistent with published, clinical research.*
For adults, take one (1) tablet daily, at bedtime as Melatonin may produce drowsiness. Do not exceed recommended dose. As a reminder, discuss the supplements and medications you take with your health care providers.
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