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DIM®
Bioavailable Diindolylmethane

60 Capsules
Promotes Healthy Estrogen Metabolism*
Product #055122

PRODUCT BENEFITS
As an Indole, diindolylmethane is a natural constituent of plants, particularly cruciferous vegetables. This bioavailable, patented form promotes healthy estrogen metabolism for women and cellular health.*

STRUCTURE AND FUNCTION
The compound 3,3-Diindolylmethane is a dietary indole which occurs naturally in Brassica vegetables. Brassica vegetables are also known as cruciferous vegetables and include broccoli, cauliflower, cabbage, turnips, kale and brussels sprouts. These vegetables are considered by many scientists to be among the most metabolically healthful foods because of their unique profile of naturally occurring biochemicals. Diindolylmethane is a stable dimer (double molecule) of indole-3-carbinol (I3C), which is generated upon hydrolysis of glucobrassicin, the indole glucosinolate in Brassica vegetables. Dehydration of I3C results in a mixture of oligomeric products, including diindolylmethane. Diindolylmethane has been shown to have beneficial enzymatic interactions in vitro, which is believed to help mediate its positive effects on estrogen metabolism.*

CLINICAL EVIDENCE

  • A randomized, double-blind, placebo controlled, clinical study analyzed healthy estrogen metabolism in 20 postmenopausal women. Subjects were given either 108 mg/day of Diindolylmethane as DIM® or a placebo. DIM® treated subjects showed a significant increase in levels of 2-hydroxyestrone (p=0.020) and diindolylmethane (p=0.045), and an increase of 47% in the 2-hydroxyestrone/16-alpha hydroxyestrone ratio (p=0.059). Based on these results, the authors concluded that DIM® had positive effects on estrogen metabolite ratios. (Dalessandri et al, 2004)
  • In a double-blind, placebo-controlled, crossover study, 33 subjects received 60 mg of DIM® or placebo per day in four divided doses. Each study period lasted three months. At three months, a significant positive effect was observed on estrogen metabolism in the treatment group. No significant effect was observed in the placebo group. (Zeligs et al, 2005)

SUMMARY
PhysioLogics DIM® utilizes BioResponse-DIM®, a bioavailable form of Diindolylmethane, that helps promote healthy estrogen metabolism and cellular health.*

DIRECTIONS
For adults, take one (1) capsule three times daily, preferably with meals or follow the advice of your health care professional. As a reminder, discuss the supplements and medications you take with your health care providers.

WARNING
Not intended for use by pregnant or nursing women. If you are taking any medications, planning any medical or surgical procedure or have any medical condition, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur.

DIM® and BioResponse-DIM® are trademarks of BioResponse.

REFERENCES
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Zeligs MA, et al. JAMA. 2005. 8(1): 5-15